Metrology for the characterisation of Biomolecular Interfaces for Diagnostic Devices
In-vitro diagnostics are vital for the drive for cost-effective healthcare, point of care monitoring and personalised medicine. The diagnosis and management of medical conditions is becoming increasingly reliant upon the detection and measurement of biochemical markers, or targets.
There are three main issues with current diagnostic devices:
- Measurements of the interface
- Repeatability and Reproducibility of Assays
- Diagnostic performance
Click here to see the papers that have been published from the work of HLT04-BioSurf
Shell thickness determination of core-shell
nanoparticles:
The attachment of proteins to nanoparticles is of
increasing interest in medicine for applications such as drug delivery and
diagnostics, and for understanding how performance and potential toxicity are
affected by the unintentional acquisition of a protein corona from biological
mediums. All of the above require a thorough characterisation of protein layers
on nanoparticles with both accuracy and precision for efficacy and safety. Our
efforts are focused upon developing measurement techniques to enable useful
characterisation using model systems.
