Metrology for Raman Spectroscopy
Raman spectroscopy is primarily used as a qualitative tool in the pharmaceutical, healthcare, biotechnology, nanotechnology, medical technology and forensic science sectors to identify and map distribution of substances in 2 or 3D. However, Raman spectroscopy lacks traceability so it is not accepted by the regulatory bodies for approval of drugs. Although standards exist, the instrument manufacturers and users do not use them as they do not cater to their needs. Instrument manufacturers categorically mention the need for spatial resolution, depth resolution and confocality measurement standards which do not currently exist.
There are strong technological needs for full chemical and structural identification of species at higher spatial resolution. In addition, high temporal resolution is also needed to investigate dynamics of chemistry and structure of the species.