This project will develop measurement methods for the research, development and quality control of biomolecular interfaces in diagnostic devices, and establish accurate, traceable and comparable methods to determine the amount of biomolecular probe immobilised at both planar and nanoparticle interfaces.
It will also investigate novel approaches for the measurement of biointerfacial structures that can be correlated with activity and binding efficiency and methods to measure and predict the activity of immobilised probes.
With the goal of supporting high throughput and multiplexed diagnostic methods BioSurf will also assess the capabilities of emerging techniques capable of detecting many targets simultaneously.
Consortium
The JRP-Consortium will also host a stakeholder workshop on the measurement of molecular adsorption at the solid-liquid interface, at the International Union for Vacuum Science, Technique and Applications IUVSTA and a special session on the analysis of biomolecular interfaces at the European Conference of Applied Surface and Interface Analysis (ECASIA13), peer-reviewed publications and conference presentations will also disseminate the results to academic and industrial audiences.
Impact
BioSurf will provide guides, standards and protocols for the quantitative analysis of biomolecular interfaces relevant to the needs of diagnostic device manufacturers. This initiates a new area of activity for European National Measurement Institutes (NMIs) and addresses the needs of the rapidly growing and competitive in-vitro diagnostic device industry within the context of the European Commission in-vitro diagnostic device directive (IVD Directive 98/79/EC). BioSurf will provide input to standards and protocols on the preparation and measurement of biointerfaces through the work carried out, proposing VAMAS interlaboratory studies, attending and contributing to relevant new work items within ISO TC201, TC212 and TC229.
